Amazing Properties of S. boulardii Yeast
Produces an enzyme that breaks down C. diff toxin A and blocks it from binding to receptors in the gut lining, helping protect against C. diff-related diarrhea.³*
Nourishes and protects the lining of the colon — including laboratory research showing it helps defend gut barrier function when under attack from harmful bacteria like E. coli.⁹*
Aids the gut’s ability to absorb water and electrolytes, restores healthy short-chain fatty acid (SCFA) levels, and boosts enzyme secretion — together supporting healthy intestinal function, firmer stools, and diarrhea prevention.¹³*
Modulates the immune system and aids in reducing gut inflammation.*
Clinical studies, including a systematic review, show S. boulardii supports gut health following antibiotic therapy — and it’s also been researched for occasional and travelers’ diarrhea, and irritable bowel syndrome (IBS).¹,²,¹³*
A meta-analysis of 18 clinical trials found that adding S. boulardii to H. pylori treatment significantly reduced side effects like diarrhea and constipation, helped more patients complete their full course of treatment, and was associated with modestly higher treatment success rates.¹⁵*
Physically traps harmful bacteria — including E. coli and Salmonella — on its own cell surface and helps carry them out of the gut through the stool.⁶*
Because S. boulardii is a yeast, not a bacterium, it’s naturally unaffected by antibacterials — making it a good companion during antibiotic treatment, when other beneficial gut bacteria are being depleted.*
Laboratory research shows S. boulardii can interfere with Candida albicans’ ability to form filaments, adhere to surfaces, and build protective biofilms.¹⁴*
Plus, the Bacillus Spores in RestorFlora
Resist being broken down by antibiotics, so they keep working even while you’re taking antibiotic medication.*
B. clausii has been studied for its role in reducing antibiotic side effects during H. pylori treatment.⁵*
B. subtilis HU58 has been studied for its role in reducing antibiotic-associated diarrhea, in both adults and children.⁷,⁸*
RestorFlora – Antibiotic Recovery and Defense
RestorFlora combines four well-studied, widely used probiotic strains: Saccharomyces boulardii, Bacillus clausii, Bacillus subtilis HU58, and Bacillus coagulans — offering comprehensive digestive support through a dual-action approach that helps maintain potency even during antibiotic use and supports your gut’s natural detoxification process.*
Several clinical studies show that the friendly yeast S. boulardii (also called Sac. b.) supports gut health during antibiotic therapy and difficult digestive recovery periods, including research specifically examining antibiotic-associated diarrhea and C. difficile-associated diarrhea.¹,²,⁴*
And a 2-week laboratory study on an earlier formulation of B. subtilis HU58 and B. coagulans SC208 — two of RestorFlora’s strains — found they helped protect the gut lining and reduce inflammation caused by antibiotic use.¹²*
Product Questions? Please see our
RestorFlora FAQ page for answers to commonly asked questions.
Convenience, Quality and Value
RestorFlora requires no refrigeration, making it easy to store, ship, and travel with. The product is made in a GMP facility to ensure maximum quality, potency and batch-to-batch consistency. We offer this physician’s-strength probiotic at the lowest pricing allowed by the manufacturer. Embrace Health Naturals has been an Authorized and Trusted Seller of Microbiome Labs products since 2017.
NOTE: For broader gut flora support alongside RestorFlora, consider pairing with
MegaSporeBiotic.
How to Use RestorFlora
Please Follow Our Usage Guide
The bottle label instructions are for general health and wellness only. Our usage guide offers additional guidance for more significant or persistent gut challenges. Please follow our usage guide, or as directed by your healthcare provider.
Use
RestorFlora is potent. For first time users, we suggest starting with less than what’s listed on the bottle – see Precautions below for details.
Take with a meal or right afterward. Capsule can be swallowed whole, or opened and mixed into food for partial amounts. Follow the Probiotic Restoration Guide above for the right amount and schedule for you, or as directed by your healthcare provider.
Precautions
RestorFlora is generally well tolerated. For first time users we recommend following the Probiotic Restoration Guide above, starting with smaller amounts, increasing gradually over two to three weeks.
As unhealthy gut bacteria are crowded out, some people notice temporary discomfort like headaches, body aches, fatigue, or loose stools — as those bacteria release toxins when they die off; this is usually a sign the product is working. If it’s uncomfortable, reduce your amount or pause until it clears, then start again slowly per your tolerance.
Taking the toxin binder
Mega IgG2000 or
GI Detox+ alongside can help absorb these die-off toxins and ease symptoms.
Do not take RestorFlora if: You have a known allergy to yeast.
Formal safety studies haven’t been done on RestorFlora for use during pregnancy or breastfeeding, so as with any new supplement, be sure to check with your healthcare provider.
For children under 5 years of age, consult with your healthcare practitioner.
Ingredients
RestorFlora Ingredients (Per Capsule)
Active Ingredients: Probiotic Blend: 370 mg 8 billion CFU (Saccharomyces boulardii 250mg, Bacillus clausii 100 mg, Bacillus subtilis HU58™ 10 mg, Bacillus coagulans 10 mg).
Other Ingredients: Pharmaceutical grade cellulose, vegetable capsule (cellulose and water).
No binders, fillers or flow agents added
Contains NO dairy, wheat, gluten, corn, salt, sugar, soy, artificial colors or flavors. GMO free
Product Usage Questions? Please see our
Probiotic Restoration Guide for all the details about using this product.
Frequently Asked Questions
Does RestorFlora help with diarrhea from antibiotics or C. diff?
Yes — this is one of the main things RestorFlora is designed to support. Several clinical studies, including a systematic review, show that S. boulardii supports gut health during antibiotic therapy, including research specifically examining antibiotic-associated diarrhea and C. difficile-associated diarrhea.¹,²,⁴ Many of our customers turn to RestorFlora during a difficult round of antibiotics or while managing a C. diff diagnosis.* For more significant challenges, some people add MegaSporeBiotic and Mega IgG2000 for broader support — available together in our
Gut Restoration Pack. The right approach really depends on your situation, so
reach out anytime for personalized guidance.*
Is RestorFlora safe to take with antibiotics?
Yes — RestorFlora’s Bacillus spores and S. boulardii yeast are both well-tolerated during antibiotic use and continue working alongside your medication. RestorFlora is specifically designed to optimize gut microbial balance during and after antibiotic use.* As always, check with your doctor or pharmacist if you have questions about your specific situation.
What’s the difference between RestorFlora and MegaSporeBiotic — do I need both?
They serve different roles. MegaSporeBiotic is our everyday, foundational probiotic for long-term gut maintenance. RestorFlora is more targeted — designed specifically to support digestive recovery during and after antibiotic use, with S. boulardii’s added diarrhea support. Many customers use them together for more complete support, especially during a difficult antibiotic course or C. diff recovery, but RestorFlora can also be used on its own when that’s the specific support you need.* For more comprehensive support, our
Gut Restoration Pack combines RestorFlora with MegaSporeBiotic and Mega IgG2000.
Can I take RestorFlora with antibacterial herbs like Biocidin or Olivirex?
RestorFlora’s Bacillus spores and S. boulardii yeast are well-tolerated alongside broad-spectrum antibiotic drugs, and the same is generally true of herbal antimicrobial remedies like Biocidin or Olivirex.* That said, if you have questions about combining specific supplements, we recommend checking with your doctor or a holistic health practitioner familiar with your situation.
Does RestorFlora have side effects? What should I expect?
RestorFlora is generally well tolerated. Some people notice mild, temporary symptoms — like loose stools, gas, or bloating — during the first week or two as unhealthy gut bacteria are crowded out; this is usually a sign the product is working. Starting with less than the full amount and increasing gradually (as outlined in our Usage Guide) helps minimize this, and symptoms typically ease once your gut adjusts.
About Microbiome Labs
Microbiome Labs was founded by microbiologist Kiran Krishnan and Dr. Tom Bayne, driven by a simple frustration: too many supplements make claims with little research behind them. That mission led to the discovery of spore-based Bacillus strains stable enough to survive digestion — the foundation of MegaSporeBiotic. The company has since pioneered spore-based probiotics and, with the backing of Novonesis, a global biotech leader, continues to invest heavily in clinical research to support its formulas. It’s why we’ve trusted and recommended their products since 2017.
Research Behind RestorFlora
A systematic review combining multiple clinical trials found that S. boulardii helps reduce the risk of diarrhea linked to antibiotic use.¹
A randomized, placebo-controlled trial in children found that S. boulardii reduced the occurrence of diarrhea during antibiotic treatment.²
Laboratory research found that S. boulardii produces an enzyme that breaks down toxin A and blocks it from binding to receptors in the intestinal lining — the toxin C. difficile produces that causes diarrhea and damage.³
A review of probiotic research examined S. boulardii’s role in antibiotic-associated diarrhea, C. difficile-associated diarrhea, and recurrent C. difficile-associated diarrhea.⁴
A 120-person clinical trial found that B. clausii, one of the species used in RestorFlora, reduced digestive side effects like nausea and diarrhea during antibiotic treatment for H. pylori.⁵
Laboratory research found that S. boulardii physically traps harmful bacteria on its own cell surface, helping remove them from the gut.⁶
Two clinical trials — one in 60 adults, one in 68 children — found that Bacillus subtilis HU58 was associated with reduced antibiotic-associated diarrhea.⁷,⁸
B. coagulans, also found in MegaSporeBiotic, has been studied as part of that formula’s clinical research on IBS and animal research on ulcerative colitis.¹⁰,¹¹
A 2-week laboratory study using a gut-simulating model examined an earlier formulation of B. subtilis HU58 and B. coagulans SC208 — two of RestorFlora’s strains — and found they helped protect the gut lining and reduce inflammation caused by antibiotic-related gut disruption.¹²
A review of published research on S. boulardii describes several mechanisms behind its effects: reducing mucosal inflammation, supporting enzyme secretion that helps prevent diarrhea, restoring healthy short-chain fatty acid levels, and strengthening tight junctions in the gut lining. The same review also describes research on S. boulardii’s role in H. pylori-related treatment, occasional and travelers’ diarrhea, and irritable bowel syndrome.¹³
Laboratory research found that S. boulardii can interfere with Candida albicans’ ability to form filaments, adhere to surfaces, and build biofilms — mechanisms relevant to fungal overgrowth.¹⁴
A meta-analysis of 18 clinical trials involving over 3,500 patients found that S. boulardii, taken alongside H. pylori treatment, significantly reduced side effects — including diarrhea and constipation — and helped more patients complete their full antibiotic course. The analysis also found a modest improvement in overall treatment success rates.¹⁵
These statements describe published research on these ingredients. They are not claims that this product diagnoses, treats, cures, or prevents any disease.
References
1. Szajewska H, Kołodziej M. Systematic review with meta-analysis: Saccharomyces boulardii in the prevention of antibiotic-associated diarrhea. Aliment Pharmacol Ther. 2015;42(7):793-801.
2. Kotowska M, Albrecht P, Szajewska H. Saccharomyces boulardii in the prevention of antibiotic-associated diarrhea in children: a randomized double-blind placebo-controlled trial. Aliment Pharmacol Ther. 2005;21(5):583-590.
3. Pothoulakis C, Kelly CP, Joshi MA, et al. Saccharomyces boulardii inhibits Clostridium difficile toxin A binding and enterotoxicity in rat ileum. Gastroenterology. 1993;104(4):1108-1115.
4. Surawicz CM. Role of probiotics in antibiotic-associated diarrhea, Clostridium difficile-associated diarrhea, and recurrent Clostridium difficile-associated diarrhea. J Clin Gastroenterol. 2008;42(Suppl 2):S64-70.
5. Nista EC, Candelli M, Cremonini F, et al. Bacillus clausii therapy to reduce side-effects of anti-Helicobacter pylori treatment: randomized, double-blind, placebo-controlled trial. Aliment Pharmacol Ther. 2004;20(10):1181-1188.
6. Tiago FCP, Martins FS, Souza ELS, et al. Adhesion to the yeast cell surface as a mechanism for trapping pathogenic bacteria by Saccharomyces probiotics. J Med Microbiol. 2012;61:1194-1207.
7. Mehta DS, de Souza A, Jadhav SS, Devale M. A Study of Probiotic Bacillus subtilis HU58 for the Management of Antibiotic-Associated Diarrhoea in Adults. The Indian Practitioner. 2020;73(4):22-28.
8. Sorensen K, Jog P, Mankar S, Holz C, Jadhav S. Effects of spore-forming probiotic Bacillus subtilis HU58™ in children with antibiotic-associated diarrhoea: a randomised, double-blind, placebo-controlled trial. Benef Microbes. 2025/2026;17(1). DOI: 10.1163/18762891-bja00086
9. Czerucka D, Dahan S, Mograbi B, Rossi B, Rampal P. Saccharomyces boulardii preserves the barrier function and modulates the signal transduction pathway induced in enteropathogenic Escherichia coli-infected T84 cells. Infect Immun. 2000;68(10):5998-6004.
10. Catinean A, Neag MA, Nita A, Buzoianu AD, et al. Bacillus spp. Spores—A Promising Treatment Option for Patients with Irritable Bowel Syndrome. Nutrients. 2019;11(9):1968.
11. Catinean A, Nita A, Buzoianu AD, et al. Probiotic Bacillus Spores Together with Amino Acids and Immunoglobulins Exert Protective Effects on a Rat Model of Ulcerative Colitis. Nutrients. 2020;12(12):3607.
12. Marzorati M, Van den Abbeele P, Bubeck SS, Bayne T, Krishnan K, Young A, Mehta D, DeSouza A. Bacillus subtilis HU58 and Bacillus coagulans SC208 Probiotics Reduced the Effects of Antibiotic-Induced Gut Microbiome Dysbiosis in an M-SHIME® Model. Microorganisms. 2020;8(7):1028.
13. Kelesidis T, Pothoulakis C. Efficacy and safety of the probiotic Saccharomyces boulardii for the prevention and therapy of gastrointestinal disorders. Therap Adv Gastroenterol. 2012;5(2):111-125.
14. Krasowska A, Murzyn A, Dyjankiewicz A, Łukaszewicz M, Dziadkowiec D. The antagonistic effect of Saccharomyces boulardii on Candida albicans filamentation, adhesion and biofilm formation. FEMS Yeast Res. 2009;9(8):1312-1321.
15. Zhou BG, Chen LX, Li B, Wan LY, Ai YW. Saccharomyces boulardii as an adjuvant therapy for Helicobacter pylori eradication: A systematic review and meta-analysis with trial sequential analysis. Helicobacter. 2019;24(6):e12651.
Why Choose Embrace Health Naturals?
- Professional grade supplements backed by clinical research.*
- Product support and guidance with all purchases.
- Family-owned since 2008 and led by a microbiologist – trusted by thousands of satisfied customers.
- Winner of the 2024 Microbiome Pioneers award from Microbiome Labs.
- No artificial colors or flavors, gluten, GMOs, cheap fillers, or low-quality additives.
- All of our products are tested for potency, purity and safety.
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