Mega IgG2000 Benefits
C. diff. Toxin Binding
Immunoglobulin G (IgG) binds destructive gut toxins, including C. diff. toxins A and B, helping neutralize them before they can damage the intestinal lining.¹ IgG also protects against gut infections, assists G.I. tissue healing and helps resolve diarrhea.*
Broad Toxin & Pathogen Binding
IgG binds to a wide range of bacteria, fungi, mold, viruses, and their associated inflammatory toxins — including LPS (endotoxins in leaky gut), H. pylori, mycotoxins (mold toxins), Staphylococcus, Salmonella, E. coli, and other pathogenic bacteria.²,⁴*
Soothes and Strengthens Gut Tissue
Clinical research shows Mega IgG2000 can reduce zonulin and I-FABP — two markers doctors use to measure gut lining damage. Lower levels mean less damage to your gut wall and tighter seals between cells, supporting healthy mucosal barrier integrity and easing leaky gut.³*
Supports IBS and IBD Recovery
Clinical studies show Mega IgG2000 is associated with improvements in abdominal discomfort, stool consistency, and diarrhea frequency in adults and children with IBS, IBD, and chronic diarrhea.⁵,⁶,⁷,⁸*
Supports Healthy Digestion
Helps the body improve nutrient digestion and absorption, particularly when gut damage has impaired the body’s ability to properly process nutrients.*
Safe from Antibiotic Drugs
The immunoglobulins in Mega IgG2000 are unaffected by antibiotics or antimicrobial remedies. It can be taken during the same course of antibiotic treatment without reducing its potency.
Backed by Real Research
Mega IgG2000 contains three different types of immunoglobulins that support healthy detoxification and gut barrier function. These immunoglobulins have been studied in 20+ published human clinical trials, case reports, and laboratory research on gut and immune health.*
Safe with Supplements and Medications
Unlike clays, charcoal and other binders that indiscriminately absorb a wide range of things, Immunoglobulins only target disease-causing bacterial components and toxins inside the gut. Mega IgG2000 only binds to microbial toxins, not to supplements, medications or food.
Dairy free. Clean and Pure
Bovine serum sourced, making it lactose-free, casein-free and B-lactoglobulin-free. Sourced from non-GMO, grass-fed cows.
Mega IgG2000 – Toxin Binding and Gut Soothing Protection
Immunoglobulin G (IgG), the most abundant antibody in the body, binds to a wide range of disease-causing bacteria, viruses, and fungi, along with their toxic byproducts — allowing the body to safely remove them through the stool.*
Unlike other milk-derived immunoglobulins on the market, Mega IgG2000 is derived from bovine serum, making it lactose-free, casein-free, and β-lactoglobulin-free.
And, unlike clays, charcoal, and other binders that indiscriminately bind to a wide range of molecules, Mega IgG2000 specifically targets disease-causing bacterial components and toxins — without absorbing supplements, medications, or food.*
A Few Things Mega IgG2000 Binds To
| Antigen |
Source |
| C. diff toxins A & B |
Toxins that damage the gut lining |
| LPS |
Inflammatory bacterial cell-wall component |
| Lipid A |
Inflammatory component of LPS |
| Pam3CSK4 |
Bacterial lipopeptide that triggers immune activation |
| H. pylori-related compounds |
Gram-negative bacteria linked to stomach irritation |
These findings describe research on the ingredient in Mega IgG2000.¹,²,⁴ They are not claims that this product diagnoses, treats, cures, or prevents any disease.*
How to Use Mega IgG2000
Please Follow Our Usage Guide
The bottle label instructions are for general health and wellness only. Our usage guide offers additional guidance for more significant or persistent gut challenges. Please follow our usage guide, or as directed by your healthcare provider.
Use
Adults and Children 2+: Please follow our
Usage Guide for this product. For general health and wellness, take 4 capsules daily with or without a meal or as directed by your healthcare provider. Children should start slowly with a lower amount; capsules can be opened and sprinkled onto food or mixed with liquids for easier dosing. For children under age 2, please consult with your healthcare practitioner.
Drink plenty of water. Can be taken with or without food, but in-between meals is best for gut toxin absorption. Capsules can be swallowed whole or emptied into water and stirred well (the immunoglobulins have a mild taste).
For G.I. calming effects: If you experience any discomfort due to gut bacterial challenges, gut imbalances, or taking probiotics, including abdominal cramping or loose stools due to changes in gut bacteria, then
INCREASING the amount of Mega IgG2000 should help ease uncomfortable symptoms. Download the
Usage Guide for complete details.
Note: if extra support is needed, a starting dose of up to 4 capsules 5 times per day (4 x 5) and an end dose of up to 4 capsules 3 times per day (4 x 3) may be used.
If using Mega IgG2000 for the first time for an active gut challenge, then two bottles are recommended. After the first two weeks, one bottle is needed per month.
Precautions
Most people tolerate Mega IgG2000 very well. If you are especially sensitive to supplements or diet changes, then starting more slowly than usual may be helpful. If adverse symptoms occur, then reduce usage amount or stop taking the product until symptoms clear, then start again slowly, as tolerated.
Bovine-based: Do not consume if you have a beef allergy or alpha-gal syndrome.
Formal safety studies have not been done on this product for use during pregnancy or breastfeeding, so as with any new supplement, be sure to consult with your healthcare provider.
Ingredients
Per 4 capsules:
- Immunolin serum-derived immunoglobulin concentrate – 2g
- Immunoglobulin G (IgG) – 900mg
- Other Ingredients: Microcrystalline cellulose, vegetable capsule (cellulose and water)
Free from the 9 major allergens (milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, soybeans, and sesame). No artificial colors or flavors. Made in the US with globally sourced ingredients.
Mega IgG2000 FAQ’s
Product Questions? Please see our
Mega IgG2000 FAQ page for answers to common questions about this product.
Frequently Asked Questions
Does Mega IgG2000 help with C. diff or antibiotic-related diarrhea?
Yes — this is one of the main things Mega IgG2000 is designed to support. Research shows its immunoglobulins bind and neutralize C. diff toxins A and B,¹ and clinical studies show improvements in diarrhea frequency and stool consistency in patients dealing with antibiotic-related and chronic diarrhea.⁵,⁶,⁷,⁸ Many of our customers turn to Mega IgG2000 during a difficult round of antibiotics or while managing a C. diff diagnosis.*
Is Mega IgG2000 safe to take with antibiotics?
Yes — the immunoglobulins in Mega IgG2000 are unaffected by antibiotics and can be taken during the same course of treatment without losing potency. As always, check with your doctor or pharmacist if you have questions about your specific situation.
What does Mega IgG2000 actually bind to?
Mega IgG2000’s immunoglobulins are well-studied for binding a wide range of harmful microbes and toxins, including LPS (a major driver of gut inflammation), C. diff toxins A and B, and H. pylori-related compounds.¹,²,⁴ Manufacturer research also points to broader binding activity against other bacteria, mold toxins, Candida and other fungal organisms, viruses, and cell-wall-deficient organisms like Mycoplasma — though these findings come from company-conducted research rather than independent peer-reviewed studies for every item.*
What’s the difference between Mega IgG2000 and a probiotic like MegaSporeBiotic — do I need both?
They work differently. MegaSporeBiotic and RestorFlora are probiotics that help rebuild and balance your gut bacteria. Mega IgG2000 is an immunoglobulin concentrate — it doesn’t contain live bacteria, but instead gently binds and neutralizes harmful toxins in the gut. Many customers use them together for more complete support, especially during a difficult antibiotic course or C. diff recovery, but Mega IgG2000 can also be used on its own.*
Is Mega IgG2000 safe if I have a beef allergy?
No — Mega IgG2000 is derived from bovine (cow) serum, so it is not a good fit if you have a beef allergy or alpha-gal syndrome.
G.I. Detox+ is a good alternative in that case.
What should I expect when I start taking Mega IgG2000?
Mega IgG2000 is generally very well tolerated. Some people who are especially sensitive to new supplements may notice mild digestive adjustment; starting with a lower amount and increasing gradually can help. If you experience discomfort while taking probiotics like MegaSporeBiotic, increasing your Mega IgG2000 amount can actually help ease those symptoms by binding die-off toxins.*
Can children take Mega IgG2000?
Children 2 years of age and older can take Mega IgG2000, starting with a smaller amount. For young children, open the capsule and mix into food or liquids as it has a mild flavor. For children under 2, please consult with your healthcare practitioner first.
About Microbiome Labs
Microbiome Labs was founded by microbiologist Kiran Krishnan and Dr. Tom Bayne, driven by a simple frustration: too many supplements make claims with little research behind them. That mission led to the discovery of spore-based Bacillus strains stable enough to survive digestion — the foundation of MegaSporeBiotic. The company has since pioneered spore-based probiotics and, with the backing of Novonesis, a global biotech leader, continues to invest heavily in clinical research to support its formulas. It’s why we’ve trusted and recommended their products since 2017.
References
1.Henderson A, Horgan A, Detzel C, Maas K, Weaver E. Serum-derived bovine immunoglobulin/protein isolate binds and neutralizes Clostridium difficile toxins A and B. Gastroenterology. 2014;146(Suppl 1):289-290.
2. Detzel CJ, Horgan A, Henderson AL, Petschow BW, Warner CD, Maas KJ, Weaver EM. Bovine immunoglobulin/protein isolate binds pro-inflammatory bacterial compounds and prevents immune activation in an intestinal co-culture model. PLoS One. 2015;10(4):e0120278.
3. Utay NS, Somasunderam A, Hinkle JE, et al. Serum bovine immunoglobulins improve inflammation and gut barrier function in persons with HIV and enteropathy on suppressive ART. Pathogens and Immunity.
4. Horgan A. Serum-derived bovine immunoglobulin/protein isolate binds to pathogen associated molecular patterns. FASEB J. 2014;28(Suppl 1):836.6.
5. Wilson D, Evans M, Weaver E, Shaw AL, Klein GL. Evaluation of serum-derived bovine immunoglobulin protein isolate in subjects with diarrhea-predominant irritable bowel syndrome. Clin Med Insights Gastroenterol. 2013;6:49-60.
6. Liaquat H, Ashat M, Stocker A, et al. Clinical efficacy of serum-derived bovine immunoglobulin in patients with refractory inflammatory bowel disease. Am J Med Sci. 2018;356(6):531-536.
7. Somsouk M, Utay NS, Shaw AL, Petschow BW, Detzel CJ, Weaver EM. Evaluation of oral serum-derived bovine immunoglobulins in HIV-infected patients with chronic idiopathic diarrhea. HIV Clin Trials. 2017;18(5-6):205-213.
8.Arrouk R, Herdes RE, Karpinski AC, Hyman PE. Serum-derived bovine immunoglobulin for children with diarrhea-predominant irritable bowel syndrome. Pediatr Health Med Ther. 2018;9:129-133.
Why Choose Embrace Health Naturals?
- Professional grade supplements backed by clinical research.*
- Product support and guidance with all purchases.
- Family-owned since 2008 and led by a microbiologist – trusted by thousands of satisfied customers.
- Winner of the 2024 Microbiome Pioneers award from Microbiome Labs.
- No artificial colors or flavors, gluten, GMOs, cheap fillers, or low-quality additives.
- All of our products are tested for potency, purity and safety.
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