HU-58 Frequently Asked Questions

Click here for ordering and shipping questions
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Click here for our probiotic comparison chart



HU-58 Ordering and Shipping Questions

No. Unlike most probiotic products, HU-58 is comprised of Bacillus spores, which are extremely hardy and heat resistant. Hot temperatures during shipping will not affect this product.

We are able to ship any of our products ordered from this website outside the United States. If you live in Canada, then most of the Microbiome Labs products can be shipped to Canada by ordering through our Direct to Patient ordering website, which is coming soon. Note that Mega IgG2000 cannot be shipped to Canada due to Health Canada restrictions on all IgG products. If you live in Canada near the U.S. border and have a delivery address inside the Untied States, we can ship you any products on this website to that address.

If you live in the United Kingdom, you can contact the product manufacturer’s U.K. division at for a list of practitioners who carry these products.

The cost of shipping depends on how much product you order and where you are shipping it to. You’ll see shipping options and prices before you finalize your order inside our shopping cart. If an item includes free shipping, that information will be clearly shown inside the shopping cart during your order. HU-58 usually ships via USPS First-Class Mail and takes approximately three business days to arrive at its destination within the United States. For more details see our full shipping policy here.

After placing a successful order you will receive an email invoice showing the details of your order. If you do not receive this email within several minutes of ordering, be sure to check the spam folder or the junk folder of your email program. If you use Gmail, be sure to check your “Social”, “Promotions” or other tabs besides your “Primary” email tab. If your email invoice is not present, please contact us and we can verify your order status.

USPS First-Class mail is the primary shipping method for the HU-58 product, unless you choose an expedited method. First-Class mail usually takes 3 business days to arrive at its destination in the U.S. Please see our shipping details for approximate delivery times.



HU-58 Product Questions

HU-58 is one of the five species of Bacillus spores found inside the MegaSporeBiotic product. HU-58 is composed of the strain Bacillus subtilis HU58™. This strain has exceptional antimicrobial, anti-inflammatory and gut reconditioning properties. The HU-58 product focuses on this single strain and provides it in a much higher potency than MegaSporeBiotic.

Using the HU-58 product in addition to MegaSporeBiotic can be very helpful when extra gut support is needed. MegaSporeBiotic alone is a better choice for a “front line” or first-choice probiotic for gut healing and balancing. But taking the HU-58 product as well can enhance the benefits of MegaSporeBiotic when dealing with stubborn, recurring challenges. If MegaSporeBiotic were a car, then HU-58 would be the supercharger that makes the car go faster.

HU-58 is best used along with MegaSporeBiotic rather than by itself. HU-58 is an “add-on” to MegaSporeBiotic to boost the effects of the MegaSporeBiotic when dealing with difficult or recurrent challenges.

If you arrived at this website through one of Michelle Moore’s books, members website, or other informational resource, then please refer to that informational resource for specific protocols and methods to address specific challenges. For the general protocol for the HU-58 product, including amounts, timing and how to use for adults and children, please click on the link below:

  • Click here for the
    Probiotic Restoration Guide
    (Adobe PDF file)

HU-58 is comprised of Bacillus spores which are very tolerant of antibiotics. Like MegaSporeBiotic, HU-58 can be taken at the same time as antibiotics. HU-58 is generally very safe and can actually support the body’s healing process and help reduce the side effects of antibiotics. For specific interactions between the prescriptions you are taking and any supplement, be sure to consult with your doctor and read the product insert for the drug in question to see if there are any contraindications.

Antibiotics are important drugs that are often helpful and are a valid treatment option. Neither Michelle nor Embrace Health, Inc. condones that you stop taking a prescribed antibiotic drug unless directed to do so by a qualified medical professional. As with any drug, antibiotics have pros and cons and side effects. It’s ultimately your decision whether to use antibiotics or not. The key is to be under the care of a medical professional no matter what methods you choose to use.

HU-58 can generally be used at the same time as other supplements. HU-58 is best used along with MegaSporeBiotic rather than by itself. If you have concerns about mixing specific supplements, consult with a holistic or natural doctor.

HU-58 withstands broad-spectrum antibiotic drugs very well without loosing probiotic potency. The same should therefore be true of antibacterial remedies of various kinds, including Olivirex and Biocidin. If you have concerns about mixing specific supplements with your probiotics, consult with a holistic or natural doctor.

The effects of taking HU-58 during pregnancy has not been studied specifically. However, probiotics in general are not only safe but very important during pregnancy and while nursing. Mothers pass on their immunity to their child through breast milk, from personal contact and during the birthing process. The spores inside HU-58 have the ability to modulate the microbiome to help improve the mother’s immune system, which is passed on to her child. Do be sure to start slowly with HU-58 (just like any other probiotic) so you do not have a cleansing reaction. If you have questions about using a specific supplement during pregnancy or while nursing, please talk with a healthcare professional who is familiar with your particular needs.

Children 5 years of age or more can take HU-58, provided that they start slowly and use a low usage amount. For details about usage for children, please refer to the “How do I use the HU-58 product?” FAQ above. If you have questions about using a specific supplement with your child, please talk with your healthcare professional.

HU-58 is a professional grade product and has a higher potency than other probiotics. The only side effect that requires caution is potential “die-off”, “cleansing” or “detox” reactions if you start at the full usage amount from day 1. The most frequently reported symptoms are intestinal cramping and loose stools. Other symptoms of G.I. detox or die-off include: gas, bloating, cramps, diarrhea and gut discomfort. For more about detox symptoms and relief, please see the What are common die-off or detox symptoms when using supplements FAQ below.

Therefore, it is highly recommended to start with a low amount and slowly work your way up to the full amount over several weeks to reduce the risk of these symptoms. For our recommended product usage, please refer to the “How do I use the HU-58 product?” FAQ above.

Taking HU-58 at the same time as MegaSporeBiotic and with food is ideal. The amino acids and carbohydrates in food help the probiotic spores move from their dormant to active form in the upper GI tract, providing immune system benefits.

HU-58 is a physician’s strength, professionally formulated probiotic supplement. When used along with MegaSporeBiotic, some people report positive results within a few days of use. However, it can take some time for your body to change the balance of it’s intestinal flora and heal itself. Also, if you don’t start slowly with this probiotic, some symptoms of gut discomfort may increase for a little while, especially if you start with the full usage amount. Probiotics alone are not a substitute or replacement for a complete program to address stubborn challenges. For best results, this program includes: immune system support, diet changes, proper cleaning and hygiene, prevention measures, professionally prescribed treatments or remedies, and the guidance of a healthcare professional.

Nutritional supplements such as probiotics are not meant to treat or “cure” any kind of disease or medical condition. The purpose of nutritional supplements is to support your body to heal itself. We have all been programmed by the media, drug companies and even our doctors to take a pill to fix our health problems. But for most difficult health challenges, this mainstream concept of taking pill X to “cure” disease Y is an incomplete and short term solution at best. It really does take a complete approach to address stubborn challenges – this is why Michelle Moore wrote her books. Rather than putting all your stock in a single supplement, it’s better to address the challenge on multiple fronts as detailed her books.

Vegetable capsules are used for HU-58. There is also cellulose in the capsule that is the prebiotic (food for the probiotics). It’s made from hypo-allergenic, Non-GMO acacia fiber.

HU-58 contains no gluten, wheat, dairy, corn, nuts, salt, sugar, soy, artificial colors or flavors.

Most probiotics on the market suffer when not refrigerated. As HU-58 is a spore form probiotic, no refrigeration is necessary. The Bacillus spores inside HU-58 are very heat stable. They can be stored in a cool, dry place inside your home. This makes shipping the product less expensive (no cold packs required), and convenient when traveling.

The product is too potent and people using it need to receive support and guidance. Be sure to review the product usage guide in the above FAQ “How do I use HU-58” and contact us if you have any questions. It’s also important to be seen by a health practitioner to monitor your progress and adjust product usage as needed. A consumer strength version of the product called Thrive is available in some stores.

The shelf life is more than 2 years.

Detoxification or die-off reactions are not uncommon when taking potent probiotics, using antibacterial supplements or remedies, or when making substantial diet changes. Note that these reactions are also referred to as detox, detox reaction, cleansing reaction, herxheimer reaction, or bacterial die-off reaction.

This reaction doesn’t happen for everyone, but if it does, it’s a good sign. It means that flora changes are happening in your gut: “bad” bacteria are dying and your body is cleaning house to remove these bacterial toxins and associated waste products. However, if this process happens too quickly, it can lead to some unpleasant symptoms.

Detox symptoms can vary widely, but for probiotics the most common symptoms are due to die-off of “bad” bacteria and include gas, bloating, cramps, diarrhea, loose stools and gut discomfort. Other general detox symptoms when taking new supplements or making healthy lifestyle changes include feeling tired, brain fog, headaches, body-aches and nausea. Unfortunately, many of these symptoms are quite similar to common infection symptoms. Therefore, it can be challenging to know for sure if you are experiencing a detox reaction or the symptoms of an infection. However, if you just started a new supplement or probiotic, or recently increased the amount you are using, slowing down or temporarily stopping use of the product will allow for any negative symptoms to subside, which generally occurs within a day or two.

Fortunately, die-off or detoxification symptoms are generally mild, largely preventable and usually temporary. The best way to avoid these symptoms is to start slowly with any new supplements or when making healthy lifestyle changes. If you do experience symptoms that are too uncomfortable, the standard practice is to reduce or stop taking the suspected supplement for a few days to see if you feel better. If you feel better after reducing the supplement, then the supplement may be started again at a lower amount or at a lower pace, if well tolerated.

If a particular supplement is still not tolerated well after starting slowly, then you may have to avoid further use of the supplement.

When experiencing detox reactions, drinking plenty of water can be helpful to aid your body in flushing out toxins. Get extra rest to allow your body time to recuperate. The GI Detox product is made with charcoal and clay and is helpful for bacterial die-off reactions because it helps “mop up” toxins in the gut. This can reduce or eliminate any detoxification or die-off symptoms.



Spore Probiotic Comparison Chart

There are four different types of spore-based products we offer. Choose the probiotic that best fits your needs based on the comparison chart. You’ll also find detailed recommended usage guides linked on the chart.

–>Please see our Spore Probiotic Comparison Chart for a detailed comparison of these probiotics.



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